Artificial insemination with donor semen (IUI/DI or Heterologous Insemination)

Artificial insemination with donor semen, also known as intrauterine insemination with donor semen (IUI/DI or heterologous insemination) is a technique in which the sperm of an anonymous donor from a sperm bank are deposited in an unnatural way in the uterus of the woman during her ovulation phase, with the aim of facilitating pregnancy.

What does Artificial Insemination with donor semen consist of?

Phase 1: Ovarian stimulation and ovulation induction

Treatment begins with ovarian stimulation, where a series of hormones similar to those produced by the woman herself (gonadotropins) are used. The stimulation must be periodically controlled, since if the number of developed follicles is very high, multiple gestations can occur.

Once one or two follicles have reached the appropriate size (18 mm in diameter) the hCG (human Chorionic Gonadotropin) hormone is administered to induce ovulation, which will occur 34-38 hours later and that is when the insemination will take place.

Phase 2: Intrauterine insemination (IUI)

The insemination in itself will be carried out within the time range in which it is estimated that ovulation will occur. That day, the semen sample obtained from an anonymous donor will be thawed. This sample will be filtered to separate the motile sperm from the rest.

The selected spermatozoa are inserted into a cannula and injected into the woman’s uterus waiting to achieve fertilization. This procedure is painless, similar to a gynecological examination.

To facilitate embryo implantation, progesterone is administered into the vagina to support the luteal phase.

Phase 3: Pregnancy

The pregnancy test will be carried out by means of a blood or urine test 14 days after the insemination. If the patient suffers from bleeding before the test, it is important that she never stops taking the medication and that she seeks advice from the medical team.

Throughout the artificial insemination treatment, her personal assistant will be available at all times to answer any questions she may have and support her in this very special moment.

fases de la inseminación artificial con semen de donante anónimo

For whom is this technique indicated?

Artificial Insemination with donor semen is indicated for

Couples where the man presents severe alterations in seminal parameters or presents azoospermia, the absence of sperm in the ejaculate.
Couples where the man is the carrier of a genetic disease that cannot be diagnosed by PGD (Preimplantation Genetic Diagnosis).
Couples who have failed other previous treatments, such as IVF-ICSI with the partner’s semen, due to a very severe male factor infertility.
Couples at risk of transmitting sexually transmitted diseases, such as Hepatitis B, Hepatitis C, Syphilis or AIDS.

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The requirements for a couple to undergo artificial insemination and have the best chance of success are:

To check the permeability of the fallopian tubes to ensure the passing of sperm for fertilization to take place, and consecutively for the zygote to reach the uterus.
To have an ultrasound scan done to rule out possible uterine malformations that could affect the implantation and development of the pregnancy. In addition, to ensure that the ovary is capable of responding to stimulation enabling the retrieval of a minimum of oocytes suitable for the performance of the technique.
To Select a semen sample from an anonymous donor bank with adequate sperm count and motility parameters, selected with a “Donor Screening” protocol that detects autosomal recessive genetic diseases.
To ensure there is no risk of contagion to the partner and/or future baby, ruling out the risk of possible hepatitis C or B, HIV, rubella (German measles), syphilis and toxoplasmosis.
The age of the woman directly influences the chances of success or failure. The chances of pregnancy using this technique begin to decrease when a woman approximately reaches 36.

Success rates

This technique offers a cumulative pregnancy rate of 45%. The success rate per artificial insemination cycle with sperm from an anonymous donor is 18%.

45% Cumulative rate

According to the Spanish Fertility Society (SEF) registry, Spain is currently the third country in Europe with the most artificial insemination treatments. Some 23,000 inseminations are performed each year.

Usually, after the insemination, the patient waits for about an hour in the room at the assisted reproduction center. Then, once at home, the woman can lead a normal life.

Once gestation is achieved, the development of the pregnancy is totally normal; the risk of miscarriage, premature delivery, or for the baby to be born with a congenital anomaly is the same as in a pregnancy obtained through vaginal intercourse.

Sperm donation is anonymous and absolutely legal in Spain, regardless of the nationality or origin of the patient. VITA collaborates with an external sperm bank where semen samples are subjected to rigorous clinical examinations.

Where do sperm donors come from?

According to the Spanish legislation on donations, sperm donors must meet certain requirements. They must be between 18 and 35 years old, in good mental and physical health, have good semen quality and not suffer from any genetic or sexually transmitted disease.

VITA uses the CEIFER sperm donor bank, whose donors go through a strict and exhaustive examination in order to guarantee the quality of the treatments. The donor will undergo various tests and studies, such as a first medical evaluation, a psychological test, a study of the sperm quality, a genetic study and a study of infectious diseases, sexually transmitted diseases, etc.

All sperm donors go through the “Donor Screening“, a Study of Autosomal Recessive Genetic Diseases Carriers. Through this test it is possible to detect the most common autosomal recessive genetic diseases. In addition, when the time comes to assign the donor, a “Genetic Matching” protocol is followed, so that the donor and the patient do not share mutations in the same genes.